【病毒外文文獻】1992 Intestinal protection against challenge with transmissible gastroenteritis virus of pigs immune after infection wit

Conference Abstracts disease using the method of Riepenhoff Talty et al J Med Virol 1981 8 212 222 in 47 children aged 6 24 months admitted with serotype 1 illness 15 with serotype 2 and 46 with serotype 4 Serotype 1 strains were subdivided into monotypes 1A and 1C Monotype 1C strains were electropherotyped There were no statistically significant differences in symptoms between serotype 1 2 or 4 infections nor between monotypes 1A and 1C nor between electropherotypes The same serotype caused similar disease severity in different years It is logical to aim for stimulation of immunity against all common serotypes in a rotavirus vaccine Intestinal protection against challenge with transmissible gastroenteritis virus of pigs immune after infection with the porcine respiratory coronavirus E Cox M B Pensaert and P Callebaut Laboratory of Veterinary Virology and Immunology Casinoplein 24 B 9000 Gent Belgium In 1984 a porcine respiratory coronavirus PRCV has emerged which is antigenically closely related to the enteropathogenic transmissible gastroenteritis virus TGEV PRCV replicates in epithelial cells in the respiratory tract and not in enterocytes in pigs of 5 weeks old or older An infection with PRCV induces antibodies which neutralise TGEV and PRCV to the same titer It was determined if PRCV immune pigs showed an intestinal protection against TGEV Therefore 6 week old seronegative pigs were inoculated by aerosol or intragastrically with PRCV and were challenged with TGEV 4 weeks later TGEV replication and or excretion could not be demonstrated for longer than 2 and 4 days after PRCV inoculation by aerosol and intragastrical respectively Non immune pigs excreted TGEV over 6 days The TGEV challenge induced rapidly a 4 to 139 fold rise in virus neutralising antibody titers in most PRCV immune pigs Experiments are in progress to elucidate the mechanism by which a PRCV infection induces a partial intestinal immunity against a TGEV infection and to examine if this immunity also is induced in the presence of maternal PRCV antibodies Studies on immune responses and interference of oral polio vaccine OPV on seroconversion to rotavirus vaccine S Migasena S Simasathien R Samakoses P Pitisuttitham C Aree and B Prayurahong Vaccine Trial Centre Mahidol University and Pramongkutklao Hospital Bangkok 10400 Thailand A randomized double blind placebo controlled trial of tetravalent human rhesus reassortant rotavirus vaccine was conducted in 330 infants to evaluate safety immunogenicity and whether simultaneous administration of OPV and rotavirus vaccine results in impaired seroconversion Three doses of vaccine 4 x 104 pfu were given to infants aged 2 4 and 6 months with oral or parenteral polio vaccine Possible vaccine reactions were recorded A seroconversion was defined as a four fold or greater rise in sera titre of IgA ELISA from pre vaccination and post dose 3 Results showed seroconversion of 12 9 in controls In rotavirus vaccine group 55 4 were seroconverted while 38 9 of infants receiving rotavirus vaccine and OPV were seroconverted The study showed an interference of OPV with RRV tetravalent immune response p 0 037 No reactions could be attributed to the rotavirus vaccine 292 Vaccine Vol 10 Issue 4 1992