【病毒外文文獻】2014 Marmoset model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection

the distillery SciBX Science Business eXchange Copyright 2014 Nature Publishing Group 1 This week in techniques Approach Summary Licensing status Publication and contact information Disease models Marmoset model of Middle East respiratory syndrome coronavirus MERS CoV infection The common marmoset could be useful as a model organism for studying MERS CoV infection MERS CoV does not replicate in wild type mice hamsters and ferrets and current nonhuman primate models only develop mild respiratory disease In marmosets infection with MERS CoV resulted in severe respiratory disease with progressive pneumonia and extensive lung pathology The infected marmosets showed greater disease severity disease duration and viral loads in the lung than infected nonhuman primates Next steps could include evaluating therapeutic strategies for MERS CoV in the marmoset model SciBX 7 36 doi 10 1038 scibx 2014 1079 Published online Sept 18 2014 Patent and licensing status unavailable Falzarano D et al PLoS Pathog published online Aug 21 2014 doi 10 1371 journal ppat 1004250 Contact Vincent J Munster National Institutes of Health Hamilton Mont e mail munstervj niaid nih gov Contact Heinz Feldmann same affiliation as above e mail feldmannh niaid nih gov